Metabolic Disorders in Schizophrenia
Metabolic Disorders in Schizophrenia: Relationship to Atypical Antipsychotic Treatment
Posted 07/28/2004
Henry A. Nasrallah, MD; Martin L. Korn, MD
Introduction
Even prior to the introduction of neuroleptic medications in the 1950s, there was evidence that individuals with schizophrenia suffered from a variety of medical and metabolic disorders at rates higher than the general population. Investigators in the early 1900s observed that patients with dementia praecox had increased rates of abnormal glucose tolerance tests,[1-3] and more recent studies have found an increased rate of type 2 diabetes in schizophrenic patients compared with the general population.[4] Studies have shown that first-episode, never-medicated schizophrenia patients have increased visceral adiposity,[5,6] impaired fasting glucose tolerance, and are more insulin resistant than healthy comparison controls.[7] Other factors such as increased smoking,[8] sedentary lifestyle, and lack of self care increase the risk even further. Therefore, due to a confluence of health and lifestyle factors, individuals with schizophrenia are at high risk for a variety of untoward health consequences.
Fuente: MedScape
Texto completo: http://www.medscape.com/viewarticle/483780?src=mp















